Join to apply for the Principal Scientific Software Engineer role at Roche1 day ago Be among the first 25 applicantsJoin to apply for the Principal Scientific Software Engineer role at RocheThe PositionA healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organizations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximizing these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness this transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.The Analytics and Workflows group within the Center of Excellence (CoE) is dedicated to turning complex data into actionable insights that advance drug discovery and development. We leverage cutting-edge high-throughput technologies and foundational multimodal machine learning models to analyze large-scale biological data, enabling deeper understanding of disease mechanisms and the identification of novel therapeutic opportunities. Despite advances in these fields, however, transforming raw data and computational models into meaningful biological insights remains a key challenge. In this role, you’ll work at the intersection of data science, biology, and engineering to build innovative analytical tools that bridge the gap between data generation and biological interpretation—helping unlock new avenues for scientific discovery and impact.The OpportunityWithin this group, you’ll collaborate with a cross-functional team to design, develop, and deploy robust tools that empower scientists to explore, visualize, and interpret complex biological datasets and models—ranging from spatial transcriptomics and high-throughput chemical screens to real-world clinical data. While you won’t be expected to be an expert across the full technology stack, we value fluency across boundaries. Depending on your background, your work may focus more on front-end or backend engineering, and could include:Engaging directly with scientists—at the bench or the keyboard—to understand and clarify emerging (and sometimes ambiguous) analytical needsIdentifying, evaluating, and applying emerging technologies to analyze and visualize biological and chemical data in support of drug discovery and developmentDesigning and implementing modular, extensible platforms that allow biologists and data scientists to access, share, and interpret computational results, abstracting technical complexity while enabling scientific insightBuilding scalable, high-performance data pipelines and backend systems, including APIs and services, to efficiently process and deliver large-scale, multimodal biological dataCreating intuitive, interactive visualizations that integrate diverse biological data types (e.g., spatial imaging, transcriptomic, clinical), helping scientists explore hypotheses and uncover insightsCollaborating across distributed scientific, engineering, and design teams to support end-to-end development—from early exploration to production-ready applicationsWho You ArePh.D. in Data Science, Mathematics, Statistics, Computer Science, Life Sciences, Chemistry, Public Health, or a related field, with 2+ years of relevant experience; alternatively, a Master’s degree with 5+ years of relevant experienceStrong analytical intuition for extracting meaning from complex datasets, coupled with the ability to communicate insights effectively across disciplines and backgroundsProficient in using Python and/or R to transform and analyze complex biological datasets, with a solid understanding of software engineering principles such as modular design, testing, and version control in collaborative, production-oriented environmentsExperienced in building static and interactive visualizations using modern libraries and tools (e.g., D3.js, Vega-Lite, WebGPU, Plotly; Shiny, ggplot2; Streamlit, Dash, Altair, Seaborn, Bokeh)Preferred expertise building intuitive front-end applications using modern JavaScript or TypeScript frameworks (e.g., Svelte, Vue, React), with seamless integration of interactive web-based visualizations (e.g., D3.js, WebGL, WebGPU)Preferred experience in backend development with Python, including building scalable APIs using frameworks such as FastAPI and GraphQLPreferred familiarity with cloud platforms (e.g., AWS, Azure, GCP) and containerization technologies (e.g., Docker, Kubernetes)Comfortable collaborating with AI/ML scientists to integrate outputs from machine learning models—such as embeddings, classifications, or generative outputs—into user-facing tools that enable model interpretability and interactionBonus: Experience designing tools or workflows that leverage AI—such as LLMs or agentic systems—to assist with biological data exploration and interpretationCurious, eager to grow new skills, and excited to explore emerging technologies while collaborating across diverse, multidisciplinary teamsThe expected salary range for this position based on the primary location of California is $162,600 and $ 302,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.BenefitsRelocation benefits are available for this posting.This position requires being onsite 3 days a week.Please provide a Cover letter and a Link to your personal website, URL and GitHub in your application **#ComputationCoEGenentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.Seniority levelSeniority levelAssociateEmployment typeEmployment typeFull-timeJob functionJob functionResearch, Science, and EngineeringIndustriesPharmaceutical Manufacturing, Biotechnology Research, and Medical Equipment ManufacturingReferrals increase your chances of interviewing at Roche by 2xGet notified about new Principal Software Engineer jobs in South San Francisco, CA.San Mateo, CA $201,400.00-$302,000.00 1 month agoSoftware Engineering Manager II, Front End, Google CloudSan Francisco, CA $197,000.00-$291,000.00 2 weeks agoSoftware Engineering Manager, InfrastructureDirector/Senior Director, Machine Learning and EngineeringSoftware Engineering Manager, InfrastructureSan Leandro, CA $150,000.00-$165,000.00 2 weeks agoSan Francisco, CA $177,000.00-$251,000.00 2 weeks agoSan Mateo, CA $200,000.00-$315,000.00 20 hours agoSan Mateo, CA $130,000.00-$280,000.00 2 weeks agoStaff Software Engineering Manager, YouTubeManager, Software Engineering, Media PlatformSoftware Engineering Manager - Backend ServicesFoster City, CA $241,000.00-$289,000.00 2 days agoSoftware Engineering Manager, Machine LearningMenlo Park, CA $177,000.00-$251,000.00 2 weeks agoSan Mateo, CA $130,000.00-$300,000.00 3 days agoManager, Engineering - Community Support EngineeringSan Francisco, CA $204,000.00-$255,000.00 3 days agoSan Francisco, CA $250,000.00-$300,000.00 1 day agoSoftware Engineering Manager, Machine LearningManager, Software Engineering (Integrations Platform)Engineering Manager (Hands‑On/Tech Lead)San Francisco, CA $200,000.00-$250,000.00 6 days agoManager, Software Engineering, Computer VisionSoftware Engineering Manager, Machine LearningSan Francisco, CA $177,000.00-$251,000.00 3 weeks agoSr Director, Flight Software EngineeringManager, Software Engineering, Messaging InfrastructurePalo Alto, CA $195,000.00-$343,000.00 2 weeks agoEngineering Manager, Agent Software EngineeringSan Francisco, CA $300,000.00-$375,000.00 2 weeks agoManager, Software Engineering, Growth NotificationsSenior Software Engineering Manager, Global Money MovementSan Francisco, CA $172,800.00-$297,000.00 2 weeks agoSan Francisco, CA $167,700.00-$224,900.00 1 month agoWe’re unlocking community knowledge in a new way. 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