Ph3bPosition Purpose /b /h3 pAs the Global Head of Pharma Technical Development Synthetic Molecules (PTDC), you are an enterprise leader responsible for the strategic direction, development, and clinical manufacturing of Roche’s Synthetic Molecule portfolio. This triple‑impact role leads end‑to‑end technical development (CMC) for small molecules, oligonucleotides, and peptides while simultaneously serving as PTD Basel Site Head. /p pYou are also responsible for the internal manufacturing of launch and commercial supply of drug substance for the synthetic molecules. /p pYou are the primary accountable leader of the new Synthetic Molecule Facility (SMF), ensuring it is delivered on time and on budget to achieve Pharma Ambition. You act as a catalyst for collective leadership within PTD, bridging the gap between early‑stage innovation and commercial launch excellence. /p h3bKey Responsibilities /b /h3 p1. Synthetic Molecule Portfolio End‑to‑End Development /p ul liLead the vision and execution for synthetic molecule drug substance, from discovery support and clinical manufacturing to commercial launch and lifecycle management. /li liEnsure “Right First Time” (RFT) delivery of CMC packages for NMEs and line extensions, directly contributing to Roche’s overall RD excellence goals. /li liDrive next‑generation synthetic capabilities, including digital automation, “Lab to Plant” models, and sustainable green‑chemistry processes. /li /ul p2. Basel Site Leadership (PTD Site Head) /p ul liServe as the single point of accountability for all PTD site‑related matters in Basel, including oversight of quality, safety, sustainability, and infrastructure. /li liRepresent PTD and site interests at the Basel Kaiseraugst Management Meeting. /li liFoster a high‑performing organization, lead employee training, engagement initiatives, and cultural transformation to make Basel a talent magnet for the global PT network. /li liOversee operational health of all PTD Basel labs and pilot plants, ensuring they meet evolving portfolio needs. /li liOwn Basel site IT/OT investments related to ASPIRE, cyber‑security, and business continuity, and be accountable for associated delivery. /li /ul p3. Synthetic Molecule Facility (SMF) Project Owner /p ul liFull delivery responsibility for the new SMF, meeting all milestones on time, on budget, and fully compliant. /li liEnsure a seamless transition from construction to clinical/commercial production, integrating the facility into the global Clinical Supply Center and commercial drug‑substance network. /li /ul p4. PT SHE Governance SPOC /p ul liServe as the Senior Point of Contact for the PT Safety, Health, and Environment Council. /li liChair the PTD SHE Governance body and drive Roche’s SHE strategy across geographies, prioritizing carbon‑footprint reduction and zero‑accident culture through safety behaviors. /li /ul p5. Community and Collective Leadership /p ul liPartner across PT and PTD networks to simplify the landscape and remove silos. /li liModel best practices in talent and leadership development across PT/D. /li liAct as primary partner for RD units and Late‑Stage Portfolio Committee members on synthetic molecule viability and technical risks. /li liEmbed Lean/operating‑excellence principles to achieve 100 % productivity targets, scaling capacity without proportional cost increases. /li /ul h3bWho You Are /b /h3 ul liPh.D. in Chemistry, Chemical Engineering, or a related life sciences field with equivalent relevant work experience in a global setting. /li liExtensive years in the pharmaceutical industry, with many years in senior executive leadership; deep expertise in synthetic molecule CMC (small molecules/oligos/peptides) and parenteral operations is preferable. /li liSeasoned leader who models a “visionary, architect, catalyst, coach” leadership style and can lead through others in a matrixed, global environment; strong ability to motivate and inspire. /li liDemonstrated track record of delivering large‑scale capital projects (e.g., manufacturing facilities) on time and on budget. /li liStrong experience managing complex sites, including SHE, quality, and employee engagement responsibilities; excellent stakeholder‑management track record. /li liExceptional ability to influence and foster constructive relationships with heads of RD units and Global Technical Operations leaders, with outstanding communication skills across all levels. /li /ul h3bSuccess Metrics /b /h3 ul liDeliver early and late‑stage portfolio on time and RFT. /li liNo first‑cycle approval delays due to synthetic drug‑substance CMC issues. /li liSMF completion and validation according to the master schedule. /li liMeeting or exceeding PTD compliance, sustainability, and safety targets. /li liVerifiable people development and growth in Basel site and PTD engagement scores and retention. /li /ul pbRoche ist ein Arbeitgeber, der die Chancengleichheit fördert. /b /p /p #J-18808-Ljbffr