Job Description Summary
Location: Basel, Switzerland #onsite
Role Purpose
As a global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented, performance driven people. All of which makes us one of the most rewarding employers in our field. The position is within the Global Technical R&D department of Novartis Global Drug Development. Chemical & Analytical Development (CHAD) plays an essential role in the development of processes for manufacturing and analysis of complex small molecule drug substances from the time it leaves the discovery laboratory until it is handed over to Commercial Production. In this position you will play an important role in developing chemical synthetic processes for the manufacture of our future drugs substances with a focus on bio-conjugation products. Antibody-Oligonucleotide constructs will be the core focus of the position.
Major accountabilities
* With your strong expertise and skill in laboratory operations, you take an important role in defining future manufacturing processes and strategies for bioconjugation projects such as Antibody-Oligonucleotides.
* In our labs, you will generate essential synthetic and partly analytical data to evaluate and define the manufacturing processes for bioconjugations providing best possible quality, efficiency and environmental compatibility.
* As a member of drug substance team, you collaborate closely with our internal and external partners to ensure timely and quality delivery of new oligonucleotide drugs to our patients.
* Further, he/she provides relevant documentation of experiments and related information in support of filing and patents.
* He/she also actively maintains and optimizes our lab infrastructure ensuring safe and efficient execution of chemical experiments.
Education
* Minimum requirement is successful completion of a relevant apprenticeship (e.g. Laborant Chemie/ Analytik EFZ or equivalent). Position is also open to applicants with completed BSc. or MSc.
Experience
* In addition the ideal candidate would have the following professional experience:
* 3-5 years experience in synthesis/chemical process development is a strong requirement.
* Proven knowledge in space of bioconjugation or chemical modification of fermentation products, e.g. Antibody-Drug Conjugations or other complex molecular structures is desirable.
* Advanced knowledge of software and computer tools such as Office package, chromatography data-evaluation software (e.g. Chromeleon) is desirable.
* Experience in use of SEC chromatography or other relevant analytical techniques is also a benefit.
* Independent and self-motivated work style with team orientation and adequate communication style.
* Good documentation skills required during execution of experiments and documentation of results.
Languages
* Adequate knowledge of English language is required (oral and written), German and other language skills are beneficial.
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