Overview
PhD Position in Advanced 3D Organotypic Bone Models for In Vitro Osteosynthesis Research. The Laboratory for Bone Biomechanics (LBB) at the ETH Zürich Institute for Biomechanics offers a PhD position in 3D bone tissue engineering. This project is embedded within the SNSF Interdisciplinary Project Facilitating a paradigm shift in osteosynthesis: Controlling biodegradation of magnesium alloys and their local effect on surrounding tissue (Nr. 10007007; project start 01.10.2025).
Focus: development of advanced organotypic in vitro bone models to study degradable osteosynthesis systems based on magnesium (Mg) alloys, aiming to reduce in vitro–in vivo discrepancies and enable clinical translation of REE-free Mg-based implants.
Responsibilities
* Develop 3D organotypic bone models to reduce IVIVD in studying magnesium alloy biodegradation.
* Establish bioreactor-based culture systems replicating in vivo conditions (pH, Mg ion concentration, pressure).
* Analyze material–cell interactions under dynamic loading using analytical and molecular techniques.
Qualifications
* MSc degree in biomedical engineering or related discipline.
* Experience in tissue engineering and cell culture is required.
* Experience with data analysis in Python is advantageous.
* Experience with imaging (especially CT) and/or image analysis is advantageous.
* Excellent communication skills in English (oral and written).
* High motivation and strong interest in skeletal research; ability to solve complex tasks independently.
* Familiarity with a cross-cultural/interdisciplinary environment is an advantage.
We offer
* Access to state-of-the-art research infrastructure, including bioprinters, imaging platforms, and advanced cell culture facilities.
* Collaborative multidisciplinary team and regular interaction with project partners.
* Enrollment in the PhD program of ETH Zürich.
* Supportive, family-friendly working conditions and a diverse, exciting environment.
Diversity and Sustainability
ETH Zurich is committed to an inclusive culture, equality of opportunity, and a respectful environment. Sustainability is a core value, with ongoing efforts toward a climate-neutral future.
Curious? So are we.
Application and Contacts
We look forward to receiving your online application with the following documents:
* University transcripts
* Names and contact details of two references
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
Further information about the Laboratory for Bone Biomechanics can be found on our website.
Questions regarding the position should be directed to Prof. Dr. Ralph Müller at ram@ethz.ch (no applications).
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