You will be responsible for providing critical biochemical and cell assay data for multiple drug discovery projects using state-of-the-art technologies. This is a lab-based role involving independent design, execution and interpretation of scientific experiments. Furthermore, you effectively communicate your findings and recommendations as part of a multi-disciplinary project team. Your work provides crucial data about protein activity in cellular assays. You develop and implement these assays by using a diverse set of formats and readouts, ranging from low- to high-throughput. You work in a highly collaborative, team-oriented and fast-paced startup environment with a strong commitment to delivering in ways that cut across traditional industry boundaries.
What you’ll do…
* Perform and develop biochemical and cell-based functional assays (96- or 384-well plate format) for screening and pharmacologically characterize molecules for drug discovery or technology development projects.
* Highly experienced with human cell lines and cell culture work combined with handling pipetting robots and high-end analytical instruments like plate readers.
* Independently design, plan, perform and analyze cell-culture experiments and assays in the context of cancer models.
* Ensure own work is compliant with General Laboratory Standards, Safety, Health and Environment standards and all other relevant internal standards and external regulations.
* Deliver work on time and within the allocated budget.
* Perform statistical data analysis and interpretation of analysis results.
* Determine SOPs, reports and presentations.
* Perform maintenance of high-end laboratory devices and instruments.
* Comply with industry standards of good research practice principles, including relevant documentation procedures in an ELN system.
* Maximize value extraction from every measurement in the lab.
What you Bring…
* Ideally MSc degree in biology/oncology or lab technician training with relevant hands-on experience in the lab.
* Minimum of 2 years industry experience in a drug discovery environment
* Experience and in-depth technical knowledge of biologics assay development and validation, screening and use of automation, with a commitment to quality and scientific rigor.
* Strong hands-on experience in cell-based assays (e.g., cell culture techniques, viability and phenotypic assays, FACS, etc.).
* Ability to solve challenges creatively and a drive to contribute to the development of new and improved assay technologies and processes.
* Experience in biochemical and molecular biology methods (e.g., ELISA, WB and enzyme assays)
* Experience in biochemical assays like HTRF, AlphaLISA and AlphaScreen is a big plus.
* Experience in high throughput technologies and automated liquid handling systems is a plus.
* Knowledge of statistical data analysis and experimental design (DoE) is of advantage.
* Strong computer, scientific, and organizational skills with great attention to detail.
* A proactive, independent, structured and highly motivated approach to work combined with excellent problem-solving skills and great team spirit.
* Strong team player with good communication skills and experience of working in multi-disciplinary teams and contributing to collaborations.
* Fluency in spoken and written English is mandatory. Fluency in Italian is a plus.
* Demonstrate independent judgment in technique and method selection, protocol and study design and execution, data analysis and use of standard practices and procedures for a variety of problems of moderate scope and complexity to meet assigned objectives.
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