Principal Scientist Head of Computational Chemistry Argau Canton Switzerland Permanent job
The company
The company is a rapidly growing biotech company focusing on solving structures of membrane protein drug targets (e.g. GPCRs ion-channels and transporters) for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression purification and engineering and preferential access to synchrotron and free electron laser beamlines for X‑ray analysis and cryo‑EM facilities they characterize the interaction of small molecules and biotherapeutics with drug targets in time to impact the discovery of novel therapeutics.
Key tasks and responsibilities
* Utilize modern molecular modelling methods to support different stages of R&D programs.
* Collaborate effectively with other functions to advance research discovery projects expeditiously from early target assessment to hit‑to‑lead and lead optimization.
* Design lead and drive computational studies on projects throughout the several discovery phases and ensure execution on agreed deliverables.
* Set the vision and strategy for computational chemistry.
* Manage data warehousing for lead discovery projects using CDD Vault to facilitate secure and efficient data management and collaboration.
* Collaborate with external partners on joint drug discovery projects.
* Present plans and results internally including at board level and externally at conferences.
* Keep up to date with the latest scientific advances and trends in drug discovery to deliver the next-generation therapies.
Your qualification
* MSc / PhD in a relevant scientific discipline (Pharmaceutical Sciences Chemistry Computational Chemistry) with a solid foundation in molecular modelling built in a pharma / biotech / CRO setting.
* Expert knowledge in CADD software packages and modern molecular modelling techniques.
* Sound knowledge in cutting‑edge cheminformatic tools AI / ML‑enabled technologies and in silico drug design including both structure‑ and ligand‑based methodologies.
* Passion for drug discovery with a deep understanding of membrane protein drug targets (e.g. GPCRs ion‑channels and transporters).
* Mastery of all the theoretical and practical principles of medicinal chemistry and drug design.
* Broad knowledge of biophysical biochemical and cell‑based assays used in the early stages of the drug discovery process.
* In depth understanding of multi‑parameter optimization and ability to integrate disease biology ADME / DMPK and toxicology data to solve complex drug discovery problems.
* Excellent leadership management organizational and team‑working skills and a talent to deliver project milestones within the expected time frame.
* Demonstrated track record of scientific publications.
Benefits
* You will be working for an innovative company aiming to discover new generation medic
* You will be working with state‑of‑art technologies
* You will be working in a supportive and dynamic team
* Share options bonus
If you are interested please send a CV.
It is essential that applicants hold entitlement to work in Switzerland. Please quote job reference 156433 in all correspondence.
Employment Type: Full Time
Vacancy: 1
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