Ph3About HAYA Therapeutics /h3 pAt HAYA Therapeutics, we are revolutionizing RNA-guided genome-targeting therapies to treat fibrosis, heart failure, and other serious chronic diseases associated with aging. Our innovative platformleverageslong non-coding RNAs (lncRNAs) - key regulators within the dark matter of the genome - to develop first-in-class, highly specific therapies that reprogram disease-driving cell states into a healthy and resilient state, tackling disease at its roots. /p pFollowing the successful close of our Series A financing, HAYA is well-positioned to advance our pipeline and execute on key scientific and operational milestones, including the advancement of HAYA’s lead program, HTX-001, toward the clinic for the treatment of non-obstructive hypertrophic cardiomyopathy (nHCM). /p pIn recognition of our scientific innovation and potential global impact, we have been named one of the 100 early-stage companies selected for the World Economic Forum’s 2025 Technology Pioneers. /p pAs a fast-growing biotech, we offer an entrepreneurial, science-driven environment whereyou’ll have a direct impact on shaping our programs and advancing the future of RNA medicine. /p h3Position Summary /h3 pHAYA Therapeutics is seeking a highly experienced, senior-level data science leader to take a prominent and highly visible role within the Data Science team. This position exists to ensure that complex preclinical and translational datasets are transformed into high-quality, decision-ready scientific outputs that support program advancement, platform positioning, and external engagement. /p pIn this strategic role, you will act as a scientific gatekeeper for data and materials generated in the cardiac and cardiorenal space, ensuring rigor, consistency, and scientific credibility across multiple therapeutic programs. /p pYou will serve as a senior scientific authority at the interface of computational biology and cardiac disease biology. Acting as a bridge between data science and biology, you will apply deep domain knowledge and multi-omics expertise to interpret complex datasets, guide analytical strategy, and ensure biological accuracy and translational relevance. /p pThis role requires strong judgment, autonomy, and the ability to set analytical standards, particularly for cardiac-focused preclinical and translational research, while partnering closely with biology, translational, and clinical stakeholders. /p pA core component of this role is creating and owning high-impact scientific content and narratives for board-level discussions, alliance management, and business development. You will take complex, multi-layered scientific analyses and translate them into clear, compelling stories that explain the 'why', 'so what', and strategic implications behind the data. /p pThis role requires the ability to frame scientific results within a broader platform and program context, connecting individual analyses into coherent narratives that articulate the value, differentiation, and trajectory of HAYA’s science. You will ensure that all scientific storytelling is accurate, rigorous, and aligned with the company’s strategic objectives. /p pYou will play a highly visible role in representing HAYA’s scientific capabilities to internal leadership and external partners, tailoring scientific stories for senior technical and non-technical audiences while maintaining the highest standards of scientific integrity. /p h3What’s in it for me? /h3 pThis role offers a rare opportunity to operate at the intersection of science and business, serving as a bridge between complex biological data and strategic decision-making. You will not only analyze and interpret science, but also shape how HAYA’s platform, programs, and data are translated into clear narratives that inform leadership, partners, and investors. /p pYour work will directly influence program direction, business development opportunities, and how the company’s scientific value is communicated externally. This is a highly visible role with meaningful exposure across the organization and to external stakeholders, set within a collaborative and innovative culture that values scientific curiosity, sound judgment, and ownership, and supports your continued growth as a senior scientific leader. /p h3Key Responsibilities /h3 h3Scientific Leadership Platform Showcasing /h3 ul liStakeholder Engagement: Act as a lead scientific communicator, showcasing HAYA’s data science platform and analytical capabilities to external partners, investors, and at scientific conferences. /li liStrategic Material Generation: Drive the creation of high-quality, high-impact data packages and visualizations from analyses across multiple programs to support decision-making and external business development. /li liGatekeeper Function: Serve as the quality control gatekeeper for all outgoing material in the cardio-renal-metabolic context; review and validate computational outputs to ensure biological accuracy and rigorous standards before dissemination. /li /ul h3Translational Biomarker Strategy /h3 ul liBiomarker Identification: Lead the computational strategy for prioritizing pharmacodynamic (PD), predictive, and prognostic biomarkers from multi-omics datasets to support clinical development in the Cardio-Renal-Metabolic space. /li liTranslational Bridge: Define and execute the data strategy to translate preclinical findings (in vitro/in vivo) into clinically relevant hypotheses, ensuring alignment with industrial drug development standards. /li liPatient Stratification: Apply advanced statistical and machine learning approaches to stratify patient populations and define responder signatures for HAYA’s therapeutics in heart failure and related metabolic conditions. /li /ul h3Computational Biology /h3 ul liCRM-Focused Analysis: Perform and oversee end-to-end analysis of bulk, single-cell, and single-nuclei transcriptomics and epigenomics data, acting as a subject matter expert specifically within cardiac, renal, and metabolic areas. /li liMulti-omics Integration: Integrate multi-omics data from in-house and public sources to uncover novel biology, disease-specific cell states, and perturbation signatures relevant to cardiac diseases (e.g., HCM, HF). /li liMethodological Standards: Establish analysis strategies to handle translational datasets, setting the standard for the entire team. /li /ul h3Cross-Functional Collaboration /h3 ul liNarrative Construction: Synthesize data from multiple independent datasets to construct clear, biologically meaningful narratives for technical and non-technical audiences. /li liHigh Autonomy Ownership: Be able to drive high-quality material generation autonomously, taking over major responsibilities from other team members. /li /ul h3Education Experience /h3 ul liEducation: ul liPhD in computational sciences (e.g., bioinformatics, computer science) or life sciences with a strong computational focus. /li /ul /li liExperience Level: ul liSenior Scientist II: 6+ years of relevant industry post-doctoral experience. /li /ul /li liTechnical Expertise: ul liExpertise with the biological interpretation of multi-omics transcriptomic data (single-cell/nuclei RNA-Seq and bulk RNA-Seq in particular). /li liProficiency in R or Python and data science frameworks: HPC/cloud-based environments, Jupyter notebooks, Ai-augmented data science (e.g., Cursor, Windsurf). /li /ul /li /ul h3Biomarker Workflows /h3 ul liDemonstrated industrial experience in computational biomarker discovery pipelines, including feature selection, validation, and clinical utility assessment. /li liExperience with epigenomic data (e.g., ATAC-Seq, CUTRUN) is highly desirable. /li liExperience with ASO / siRNA-related data interpretation is highly desirable. /li /ul h3Domain Knowledge /h3 ul liIndustrial CRM Expertise: Comprehensive experience with translational and industrial/biotech settings in the Cardio-Renal-Metabolic therapeutic area. /li liTranslational Insight: Proven ability to bridge the gap between early discovery and clinical translation, utilizing computational biology to support target and biomarker validation and translation. /li /ul h3Communication /h3 ul liExceptional ability to present complex data to diverse audiences (business, clinical, scientific) and experience acting as a reviewer/approver for scientific content. /li liExceptional ability to generate high-quality data packages and results for internal and external audiences in an autonomous way. /li /ul /p #J-18808-Ljbffr