Philogen is a Swiss-Italian integrated biotechnology company founded in 1996, dedicated to developing innovative biopharmaceuticals for cancer therapy. Philochem AG is the discovery R&D center of the Philogen Group located in Otelfingen (Zurich, Switzerland). Promising preclinical candidates developed at Philochem are subsequently produced at Philogen’s authorized Good Manufacturing Practice (GMP) facilities in Siena (Italy). The Company currently sponsors and coordinates Phase I, II and III prospective clinical trials in Europe and in the United States. Despite the focus on cancer research, the company is also active in discovering innovative therapies for inflammatory conditions
Philochem operates with four key departments:
Discovery of innovative therapeutic proteins
Development of GMP-ready mammalian cell lines expressing therapeutic proteins
Creating diagnostic and therapeutic targeted small organic molecules
Bridging Biology and Chemistry to support the advancement of preclinical and clinical products
We are looking for a highly motivated to join our Biology team for a 6–12 month in the field of, with a focus on
bispecific antibody therapeutics
In this project, you will support the, including bispecific and immunomodulatory formats. Your work will contribute to the preclinical evaluation of novel therapeutic candidates. You will apply state-of-the-art techniques in, and perform a range of (e.g., T cell activation, cytotoxicity, flow cytometry) to assess biological activity. During the project, you may also be exposed to to evaluate translational potential
design, engineering, and functional characterization of next-generation antibody-based molecules
molecular cloning, protein expression, and purification
testing of selected candidates in relevant models
Your Tasks Assist in the generation of bispecific antibody constructs using molecular biology approaches
Produce and purify antibody-based molecules in mammalian expression systems
Perform in vitro functional assays (immune cell assays, reporter systems, binding assays, cytotoxicity)
Analyze experimental data and contribute to troubleshooting and optimization
Present results regularly within the internal team meetings
Collaborate closely with internal experts and academic supervisors
Your Profile Currently enrolled in a master’s program in, or a related field
Strong interest in and therapeutic antibody development
Some practical experience in, or is a plus
Familiarity with flow cytometry or immune assays is desirable but not required
Eagerness to learn, good organizational skills, and a proactive mindset
Very good command of English (written and spoken)
A focused and dynamic in a translational biotech environment
Access to and expert mentoring
cutting-edge research infrastructure
Integration into an active R&D team working on next-generation immunotherapies
Opportunity to gain real-world insights into drug discovery and antibody engineering
A collaborative and supportive scientific atmosphere
Applications will be reviewed on a continuous basis. Please send your application to Dr. Abdullah Elsayed ()
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