Summary
Location: Basel, Switzerland
Full time, onsite,
In the Immunology group in Biomedical Research, We are developing the next generation of medicines for inflammatory bowel disease with the ambition to transform the lives of patients. This is an opportunity for you to bring your scientific talent and curiosity into a highly collaborative, interdisciplinary environment, where your work will turn complex human data into actionable therapy-relevant insights in a competitive and dynamic field.
About The Role The Translational Inflammatory Bowel Disease (IBD) lab is integrated in the Immunology Research Disease Area and will accelerate target discovery and positioning of therapeutic compounds for IBD (Ulcerative Colitis, Crohn’s disease). To lead the lab research activities, we are looking for a scientist who has a strong background in mechanistic translational research in mucosal immunology. If you are passionate about the molecular basis of IBD and compound mode of action at the interface of preclinical and clinical research, we want you on our team.
Key Responsibilities
Design and execute mechanistic experiments hands-on, to link human disease biology to druggable targets within and beyond the immune system, and to accelerate preclinical compound development, strengthen understanding of drug modes of action, differentiate novel drugs to standard-of care treatment. Leverage human biosamples (e.g. blood, intestinal biopsies) to generate decision-making data and position candidate molecules for clinical trials (target validation, MoA studies, biomarker strategy). Partner closely with early clinical teams (Biomarker Development, Translational Medicine) to test clinical hypotheses for early clinical strategies (e.g. patient stratification). Champion data-driven target discovery, in collaboration with data scientists, in vivo biology labs and other groups in Novartis Biomedical Research to connect quantitative methods (e.g. ex vivo analyses