One of our main clients based in Basel is looking for a
Scientist, Mouse Genetics and Outsourced breeding management
with technical expertise to generate and validate transgenic models. The person will act as a dedicated advocate for the 3Rs, optimizing breeding colonies to ensure genetic stability and animal welfare while maintaining rigorous standards for nomenclature and molecular data.
Responsibilities
:
* Provide high-level oversight of external Contract Research Organizations (CROs) and internal breeding facilities to ensure operational excellence.
* Develop and implement optimized breeding strategies (with focus on quality, timelines and costs) to maintain genetic stability while minimizing surplus animals, aligning with the 3Rs (Replacement, Reduction, Refinement).
* Serve as the primary point of contact for external vivarium managers, troubleshooting issues related to phenotype drift, or health status etc.
* Act as internal expert for the generation of new mouse lines using cutting-edge techniques.
* Define and standardize the official nomenclature for all newly generated lines in accordance with MGI (Mouse Genome Informatics) and International Committee guidelines.
* Maintain meticulous records of genotypes and molecular validation data (e.g., NGS, Southern Blot, qPCR).
* Monitor the health and welfare of experimental cohorts, defining humane endpoints and overseeing the assessment of unexpected phenotypes in new transgenic lines.
* Develop and implement standards in housing and care of contract bred animals at external partners.
* Collaborate with therapeutic area experts to provide initial phenotypic characterization and validation of model utility.
Requirements
:
* PhD in Genetics, Molecular Biology, Biotechnology, or a related field
* Minimum 3+ years of hands-on experience in mouse genetics and colony management
* Proven track record of generating mouse models
* Strong project management skills; ability to manage multiple external vendor Relationships
* Regulatory: Familiarity with FELASA guidelines and animal welfare legislation
* Fluent written and verbal communications skills in English, German nice to have
Location: Basel
Duration: 1 year
Start date: ASAP
Home Office: No - On-site position
*While we appreciate every application, please note that due to the high volume of responses, we may only be able to contact shortlisted candidates.
**Please note that we can only consider EU/Schengen applications