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Summary
As an ADME Scientist with Biomedical PK Sciences (PKS) organization, you will facilitate the in vitro characterization of the drug-drug interaction (DDI) potential of drug candidates. The anticipation of the drug-drug interaction liabilities during the drug development process is critical in understanding the safety and efficacy profile of the new drug candidate.
The Drug Disposition (DD) group within PKS is seeking a highly qualified, multidisciplinary team-oriented scientist with cell biology experience, particularly in in vitro enzyme kinetics and ADME assays. A strong background in bioanalytical methods, including LC/MS, radio-chromatography, and PCR, is desirable. In this role, you will elucidate drug-metabolizing enzymes involved in the elimination of new drug candidates, perform enzyme kinetics studies, and assess the potential to inhibit or induce these enzymes. Responsibilities also include researching new technologies in 3D cell culture models, automation, and bioanalytics to enhance assay portfolios.
Requirements
* BS, MS, or PhD in biology, biochemistry, analytical chemistry, or related disciplines.
* Good understanding of laboratory equipment, particularly LC/MS.
* Experience handling radioactive materials and radio chromatography.
* Proficiency in cell culture work and cell-based assays.
* Experience with lab automation systems is desirable.
* Strong experimental and problem-solving skills, excellent collaboration and communication skills (both written and oral), eagerness to learn, and excellent time management skills.
* Ability to work effectively in a team-based drug discovery/development environment.
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Seniority level
* Mid-Senior level
Employment type
* Full-time
Job function
* Research, Analysis, and Information Technology
Industries
* Pharmaceutical Manufacturing
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