PhD Student in time-resolved structural biology of membrane proteins
The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting‑edge research in the fields of future technologies, energy and climate, health innovation and fundamentals of nature. By performing fundamental and applied research, we work on sustainable solutions for major challenges facing society, science and economy. PSI is committed to the training of future generations. Therefore, about one quarter of our staff are post‑docs, post‑graduates or apprentices. Altogether, PSI employs 2300 people. This PhD project is part of a recently funded SNSF Ambizione grant. Our research aims to uncover the molecular mechanisms of human daylight vision by studying light‑sensitive G protein‑coupled receptors (GPCRs). We are utilizing high‑resolution, time‑resolved structural biology methods to capture the real‑time interaction of these receptors with their signalling partners.
Your tasks
* Apply time‑resolved cryo‑EM and complementary biophysical techniques to capture dynamic structural changes during protein activation with high spatial and temporal resolution.
* Prepare samples of protein complexes for structural and biophysical studies.
* Perform cryo‑EM data collection, image processing, and 3D reconstruction.
* Integrate cryo‑EM results with additional biophysical data to obtain comprehensive mechanistic insights.
* Present research findings at national and international scientific conferences.
* Publish results in peer‑reviewed scientific journals.
Your profile
* Master’s degree in biochemistry, structural biology or a related discipline completed before February 2026.
* Experience in membrane protein biochemistry/biophysics, cryo‑EM, X‑ray crystallography or spectroscopy.
* Strong motivation to work on ambitious, interdisciplinary projects at the frontier of structural biology.
We offer
Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on‑site infrastructure. The candidate will be enrolled in the Life Science Zürich Graduate School at the University of Zürich, with a tailored PhD training program and teaching duties, and will also have the opportunity to co‑supervise students.
For further information, please contact Dr Polina Isaikina, polina.isaikina@psi.ch.
Please submit your application online by 1 December 2025 (including CV, motivation letter and addresses of referees) for the position as a PhD Student (Index‑Nr. 2300‑24782). Paul Scherrer Institute, Human Resources Management, Pascale Bärtschi, 5232 Villigen PSI, Switzerland
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