Information
In this position, you will contribute to identifying best-in-class scFvs and driving Numab’s projects towards development. You will be responsible for sequence and structure analysis for antibody engineering.
Your Responsibilities:
* Perform Sanger/NGS sequence analyses and protein structure modelling using state-of-the-art in-silico methods to gain insights and guide antibody design, selection and optimization
* Analyse in-silico and/or related experimental data sets (for example antibody xray/cryoEM/predicted structures and biophysical data sets)
* Contribute to technology development and innovations
* Develop/expand in-house data processing pipelines
* Prepare and deliver reports and presentations to guide decision-making
* Contribute to publications, conference presentations and patent applications
Ideal candidates will have:
* Deep understanding of antibody/protein structure and solid programming skills
* PhD (preferred) or MSc in computational biology, computational chemistry, theoretical chemistry, biophysical chemistry, biochemistry, chemistry, biophysics, structural biology or a related discipline with relevant industry (preferably biotech) experience
* Experience in molecular modeling, molecular dynamics simulations, docking and structural bioinformatics tools and software (Discovery Studio, Rosetta, or similar) for sequence and structural analysis and structure-based antibody design and optimization
* Substantial experience of working with Unix/Linux at the command-line and writing programs/scripts (e.g., format conversions, report/summary generation, etc.) to solve day-to-day problems
* Proficiency in statistics and able to apply it to analysis of data and results
* Familiarity with high-performance computing environments
* Experience in analysis of large datasets
* Ability to work independently, and willingness to take on tasks and responsibilities as needed in a dynamic cross-functional team environment
* A creative and innovative mindset, with a keen interest in advancing the field of biologics through cutting-edge computational methods
What we offer:
* A diverse field of activities in a dynamic team with an inspiring, entrepreneurial atmosphere.
* Flat hierarchies and expedited decision-making processes.
* The opportunity to take responsibility, help shaping and implementing solutions.
* Attractive employment conditions, superior pension plan, flexible working time model, and opportunities for further personal development.
* Performance-based bonus and participation in the employee stock option plan.
* Several fun team events throughout the year.
* A workplace near the city of Zurich, overlooking the lake.
About us
Numab Therapeutics AG is an expanding, Swiss biotech company based in Horgen, canton of Zürich. The company is focused on the discovery and development of innovative, antibody fragment-based therapeutics with a focus on inflammation and immuno-oncology. With our breakthrough antibody-discovery and multi-specifics engineering platform, we engage in proprietary projects as well as collaborative research on behalf of partners in the pharmaceutical industry.
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