Role Purpose
As a Senior Expert Science & Technology in Downstream Process Development, you will play a key role in advancing model‑based development and decision making for biologics purification processes. You will develop, apply, and deploy mechanistic and hybrid models with a strong focus on chromatography, while also covering other downstream unit operations and their interconnection into integrated process flows.
Location
Basel, Switzerland (onsite)
Responsibilities
* Develop and apply downstream process models for biologics, with a strong emphasis on chromatography (e.g., IEX, HIC, MMC, affinity) and their underlying physicochemical principles.
* Extend modelling approaches to other downstream unit operations (e.g., filtration, UF/DF, viral inactivation) and connect individual steps into integrated DSP models to support process understanding and optimization.
* Design, plan, and execute laboratory experiments to generate high‑quality data for model development, calibration, and validation, working hands‑on in the lab when required.
* Use modelling to support process design, scale‑up, troubleshooting, robustness studies, and decision making across early and late development.
* Implement and deploy models using Python, including development of user‑friendly tools or apps that enable broader adoption by project teams and stakeholders.
* Translate complex modelling results into clear, actionable insights for multidisciplinary audiences, including process scientists, project leaders, and management.
* Collaborate and communicate effectively with internal and external stakeholders, ensuring alignment between modelling activities, experimental work, and project objectives.
* Actively contribute to and help shape the global modelling community, sharing best practices, methodologies, and innovations across sites and functions.
* Contribute to scientific documentation, technical reports, and regulatory‑relevant deliverables as required.
Education & Experience
* MSc, PhD, or equivalent experience in Biotechnology, Chemical Engineering, Biochemistry, or a related field.
* Several years of experience in biologics downstream process development, with demonstrated focus on process modelling.
* Strong, hands‑on expertise in chromatography, including mechanistic understanding of separation phenomena.
Technical Expertise
* Proven experience in downstream process modelling, ideally including chromatography modelling, parameter estimation, scale‑down/scale‑up concepts, and integration of multiple unit operations.
* Ability to design and run experiments to support model development and validation.
* Strong programming skills in Python, with experience in building reusable tools, workflows, or applications for broader user groups.
* Familiarity with data analysis, visualization, and model deployment concepts is a strong advantage.
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