Contexte
The Lausanne University Hospital (CHUV) is one of five Swiss university hospitals. Through its collaboration with the Faculty of Biology and Medicine of the University of Lausanne and the EPFL, CHUV plays a leading role in the areas of medical care, medical research and training.
The Department of Oncology UNIL-CHUV brings together clinical and cancer research in a strong spirit of innovation. It comprises the services of medical oncology, immuno-oncology including advanced cellular therapies, radiation oncology, hematology including stem cell transplantation and the center for experimental therapies. It also integrates the Lausanne branch of the Ludwig Institute for Cancer Research (LICR), particularly in the field of immunotherapy.
Mission
You will work on a translational project investigating chimeric antigen receptor (CAR) T cells and other adoptive cell therapies, primarily through advanced microscopy approaches. Your responsibilities will include :
1. Visualizing the dynamics and nanoscale structure of immune synapses between engineered T cells and tumor cells
2. Investigating how different CAR constructs affect target cell killing
3. Actively contributing to internal presentations, departmental seminars, and scientific conferences
4. Assisting with the preparation of scientific publications, reports, and grant applications (in English)
5. Supporting the supervision of Master’s and PhD students and lab technicians.
What we offer
6. Close mentoring and teaching in advanced imaging techniques, including cryo-expansion microscopy, dSTORM, and live cell microscopy, with direct applications in translational immune-oncology, T cell engineering, and cell therapy manufacturing
7. A collaborative and supportive lab culture that values intellectual exchange, creativity, and autonomy
8. Participation in national and international scientific conferences
9. High quality of life in Lausanne, one of Switzerland’s most vibrant academic and cultural hubs.
Profil
10. PhD (or equivalent) in Physics, Biology, Biochemistry, Cancer Immunology, or a related field
11. Proven experience in cell culture techniques
12. Solid background in immunofluorescence and fluorescence microscopy
13. Familiarity with automated image analysis workflows
14. Prior experience in human immunology and lymphocyte engineering is a strong asset
15. Keen interest in translational immune-oncology (experience is a plus but not required)
16. Proficiency in flow cytometry and standard computational tools
17. Fluent in English (spoken and written), including scientific communication
18. Adaptable, self-motivated, and comfortable in a dynamic research environmen.
To apply, please send your application as a single PDF including :
19. A brief motivation letter
20. Your CV
21. A list of publications, and