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Cmc principal - drug substance

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Festanstellung
Discover International
Inserat online seit: 21 Januar
Beschreibung

Senior Recruitment Consultant: Supply Chain & Procurement at Discover International

CMC Drug Substance Principle

Switzerland - 3 Days onsite / 2 Days from home

We’re partnering with an innovative biopharma company seeking a Drug Substance Principal SME to provide technical leadership across development, tech transfer, and commercial manufacturing within a global CDMO network.

This role owns the technical strategy and execution of Drug Substance processes from development through commercialization.


Key Responsibilities

* Lead end-to-end Drug Substance tech transfers (site to site, development to commercial) with accountability for timelines, risks, and budgets
* Define and drive DS manufacturing strategy (upstream & downstream) to ensure robust, scalable, and cost-effective processes
* Provide hands‑on technical oversight of process development, scale‑up, validation, and ongoing manufacturing at CDMOs
* Act as the Drug Substance SME, supporting troubleshooting, deviations, CAPAs, and change controls
* Lead CDMO technical due diligence, onboarding, and governance
* Support comparability, lifecycle changes, and continuous improvement initiatives
* Provide technical input to regulatory submissions and support inspections and audits


Your Background

* 7+ years in biopharma working with biologic drug substances
* Strong experience in MSAT, process development, tech transfer, or manufacturing
* Proven work with CMOs/CDMOs and commercial production environments
* Solid understanding of cGMP and regulatory requirements
* Degree in Biotechnology, Chemistry, Biochemistry, Pharmacy, or related field
* Comfortable in a global, matrix, hands‑on environment
* Willing to travel internationally


Seniority level

* Mid‑Senior level


Employment type

* Full‑time


Job function

* Manufacturing
* Pharmaceutical Manufacturing and Biotechnology Research

Referrals increase your chances of interviewing at Discover International by 2x

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