PhD position: Development of high-throughput protein perturbation technologies
The Laboratory for Biological Engineering (Prof. Randall J Platt) of the ETH Zurich in Basel, Switzerland, develops genome engineering technologies and applies them to a range of fundamental and disease-focused areas. To advance these efforts, the Platt group is recruiting a full-time (100%) PhD Student to develop and apply methods at the intersection of gene editing, functional genomics, protein engineering, and targeted protein degradation.
Project background
High-throughput perturbation technologies rely on perturbing DNA or RNA to infer the function of proteins. Methods to directly perturb proteins, such as through targeted protein degradation, have been challenging to implement in high throughput. This project focuses on developing novel technologies combining CRISPR-Cas and targeted protein degradation for high-throughput protein perturbation, enabling prototype-to-phenotype mapping.
We are looking for a highly motivated and collaborative researcher to join a multidisciplinary team of scientists. The candidate will develop novel gene editing and targeted protein degradation methods and apply them to address fundamental biological questions and develop induced proximity therapeutics.
Profile
The ideal candidate will hold a Master’s degree or equivalent in Molecular Biotechnology, Biochemistry, Molecular Medicine, Structural Biology, Molecular and Cellular Biology, or a related field. They should have experience in several of the following areas:
* Molecular biology
* Mammalian cell culture
* Pooled CRISPR screens
* Preparation of deep sequencing libraries for functional genomics
* Targeted protein degradation and induced proximity therapeutics
* Protein quantification and characterization in mammalian cell line experiments
* Protein biochemistry and structural biology
* Bioinformatics, statistics, and programming
The candidate should be passionate about science, technology, collaboration, and communication. They must have strong motivation and interest in working with multidisciplinary scientists. Effective communication skills in English, both oral and written, as well as proficiency in scientific illustration using Adobe Illustrator or equivalent, are required.
Workplace
We offer
The position is located in the Department of Biosystems Science and Engineering (D-BSSE) of ETH Zurich in Basel, Switzerland. The D-BSSE specializes in systems and synthetic biology, bioinformatics and data science, and engineering sciences related to microfluidics and microfabrication. It is situated within a biomedical research hub with close links to top academic institutions and biotech/pharma companies such as FMI, Biozentrum, Novartis, Roche, Bayer, and Lonza. Basel is an international city with rich arts, culture, nature, and easy access to Europe.
ETH Zurich promotes an inclusive, diverse, and respectful environment. We encourage applications from all qualified candidates and support equal opportunity initiatives.
Application process
Interested candidates should submit their application online with:
* A cover letter outlining scientific interests and motivation
* CV
* Diplomas and transcripts
* Contact details of two referees
Applications via email are not accepted. For more information, visit our website. For questions about the position, contact Prof. Platt at rplatt@ethz.ch (no applications).
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