The Bio Engineering Laboratory at the Departement of Biosystems of ETH Zurich in Basel is inviting applications for a PhD position in Engineering of Microfluidic in-vitro Barrier Models for Bacterial Lung and Bladder Infections.
We are seeking a highly motivated and enthusiastic PhD student to work in a highly international environment in Basel, Switzerland.
Within the framework of a large National Competence Center of Research (NCCR) “Antiresist” (for more information, view), involving clinicians, academic, and industrial research partners across multiple disciplines, a microfluidic platform is currently being developed for studying bacterial lung and bladder infections and testing new antibacterial drugs. This platform includes a microfluidic system for culturing advanced in-vitro lung and bladder barrier models (membrane-based organ-on-chip models) and exposing them to bacteria and potential drug compounds. Various analysis methods such as fluorescence microscopy, mass spectroscopy, TEER, and permeability assays are used to analyze and monitor barrier-layer status and viability continuously.
Job description
The candidate will further develop a microfluidic platform designed for culturing transwell-based lung and bladder organoid models in collaboration with infection biologists from the Biozentrum (University of Basel). The platform will be used to study mechanisms underlying bacterial infections and antimicrobial resistance, as well as to evaluate novel treatment strategies. A key goal is to optimize the platform for translational applications suitable for testing in clinical and industrial settings.
Profile
For this interdisciplinary project, a suitable candidate should have:
* A solid background in microengineering, including plastic fabrication methods for microfluidics
* Skills in CAD design and simulation tools (e.g., COMSOL)
* Experience in cell biology, in vitro culture methods, and bioassays
* Experience in confocal microscopy and image analysis
Experience with transwell-based barrier models and biology is a strong advantage. Basic knowledge of microbiological techniques, including bacterial cultures, sterile handling, and infection assays, is highly appreciated. Strong communication skills, a proactive attitude, and the ability to work collaboratively across disciplines, along with fluency in English (oral and written), are important assets.
We offer
* The opportunity to make an impact by being part of ETH Zurich, which supports professional development and contributes to societal progress
* Active commitment to a sustainable and climate-neutral university
* Numerous benefits such as public transport season tickets, car sharing, sports offered by ASVZ, childcare, and attractive pension benefits
The group has access to a state-of-the-art cleanroom, extensive engineering and testing equipment, as well as biological facilities. Research partners within the AntiResist consortium bring expertise in lung and bladder systems and bacterial pathogens, along with biosafety facilities.
The position is planned for 4 years.
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