Description
At the Gote-Schniering Lab of the University of Bern, we are seeking a highly motivated PhD candidate to investigate immune ageing mechanisms in fibrotic lung disease.
With ageing, the lung progressively loses its regenerative capacity after injury, which can contribute to diseases such as pulmonary fibrosis. Increasing evidence suggests that immune ageing plays an important role in this process. This project will investigate how age-related changes in the immune system impair lung repair and promote fibrosis.
Using single-cell and spatial omics, imaging, and human 3D tissue models, the aim is to uncover key mechanisms and identify new therapeutic opportunities.
Tasks generate and analyze single-cell and spatial transcriptomics / proteomics datasets, perform functional assays and mechanistic perturbation experiments, work with ex vivo 3D lung tissue culture models,
contribute to experiments in in vivo mouse models, collaborate closely with researchers across immunology, lung biology, and computational biology. Requirements a Master's degree in Biology, Biomedicine, Immunology, or a related field,
hands-on experience in cell culture, molecular biology, and/or immunology techniques, a strong interest in biomedical research, disease mechanisms, and systems immunology, motivation to work in an interdisciplinary research environment,
excellent communication skills in English. The following are considered an advantage:
experience with single-cell or spatial omics,
experience with advanced microscopy / imaging,
experience with mouse models,
prior exposure to bioinformatics or data analysis.
We offer:
a highly interdisciplinary PhD project at the interface of immunology, tissue regeneration, and systems medicine,
access to cutting-edge technologies including single-cell omics, spatial profiling, and 3D tissue mod