Postdoc in Development of in Vitro Skin Model Including Sensory Perception
Postdoc Position in Development of in Vitro Skin Model Including Sensory Perception
100%, Basel, fixed-term
For a collaboration project between the Bio Engineering Laboratory (Department of Biosystems Science and Engineering of ETH Zurich in Basel) and Novartis AG, Basel, Switzerland, we are seeking a highly motivated and enthusiastic Postdoc. You will have a unique opportunity to collaborate across scientific and organizational boundaries with a focus on developing powerful advanced skin models to study barrier function and itching that have the potential of therapeutic breakthroughs for patients.
Project background
Leveraging cutting‑edge advanced cellular models, and bioengineering and microfluidic approaches, the project is aimed at developing skin models that include sensory perception for understanding immunological skin diseases and for applications in drug discovery. Current ex vivo skin models, although widely used in pharmaceutical and cosmetic research, fall short of assessing - in real‑time - itch‑inducing and barrier‑compromising conditions. Emerging models, based on primary keratinocytes and induced pluripotent stem cell (iPSC), can better replicate physiological and disease conditions. However, such models need to be adapted for pharmaceutical research and target identification.
* In this collaborative effort, you will devise an in vitro 3D human skin model to investigate barrier function under homeostatic conditions and in response to inflammatory stimuli
* By combining state‑of‑the‑art engineering and microfluidic approaches with new cellular models, you will develop new skin models that include sensory perception and will find applications in fundamental science and drug testing
* You will have a dual role in setting up and culturing the 3D skin models and optimizing sensor technology (e.g. TEER and TEWL) to enable a robust assessment of skin barrier functionality
* In addition, itch perception will be studied by the integration of iPSC‑derived sensory neurons
Profile
* Considering the dual aspects of this position, we are looking for a candidate with a strong background in biology and engineering (e.g., bioengineering, biotechnology, or related fields) with a solid knowledge of molecular biology and cell culturing, preferably in microphysiological systems
* Important experience includes primary cell culturing, work with advanced in vitro models, epithelial/endothelial barrier characterization, and iPSC differentiation; skills in optical microscopy, sensor development and integration, as well as in electrophysiology are a plus
* Academic excellence, a professional attitude, and a self‑driven nature are expected
* Strong communication skills, fluency in English, and a proactive mindset are essential for thriving in this collaborative, international environment
The position is fully funded for initially 2 years, an extension to up to 4 years is possible. The starting date is flexible but must be before 06-2026.
Workplace
We offer
* Your job with impact: Become part of ETH Zurich, which not only supports your professional development, but also actively contributes to positive change in society
* You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports offered by the ASVZ, childcare and attractive pension benefits
We value diversity and sustainability
In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish. Sustainability is a core value for us – we are consistently working towards a climate‑neutral future.
Curious? So are we.
We look forward to receiving your online application by February 15th 2026.
A complete application package includes
* A short and specific motivation statement for the advertised position (max. 1 page)
* Complete academic transcripts
* At least two reference letters (or contact details of referees).
Please note that we exclusively accept applications submitted through our online application portal. Applications submitted via e‑mail or postal services or incomplete application packages will not be considered.
Further information about the Bio Engineering Laboratory can be found on our website. For more information on the position, please contact exclusively via e‑mail: mario.modena@bsse.ethz.ch.
ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting‑edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.
In your application, please refer to Polytechnicpositions.com
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