PFounded in 1921 and headquartered in Mendrisio (Switzerland), Sintetica's mission is to continuously strive to improve therapies by enhancing its products' formulations and usability for the benefit of clinicians and patients. /p pWe do so in close cooperation with clinical experts, who shape our understanding of their unmet needs and drive our efforts to address them. With this trust and insight, we push the limits of science and technology to make therapies safer for patients and easier to perform. Every year we reliably supply millions of doses of our products across a range of therapeutic classes, including anaesthesia and analgesia, while expanding to address further healthcare needs. /p pTo strengthen our Pharmaceutical Development team at our headquarter in Mendrisio (Switzerland), we are currently looking for a strongPharmaceutical Development Laboratory Project Manager (Formulation expert). /strong /p pstrongPosition summary /strong /p pThe Pharmaceutical Development Laboratory Project Manager will operate under the direct coordination of the Pharmaceutical Development Laboratory Manager and will manage projects related to: /p ulliGalenical development of new sterile injectable drug products and ophthalmic products. /li liOptimization of formulations related to sterile liquid and semi-solid drug products already in place. /li liFormulation development of both small and macro-molecules API. /li /ulpstrongKey responsibilities /strong /p ulliCoordinate and execute the activities related to the assigned formulation development projects: ulliDefine qualitative and quantitative composition of formulations to ensure stability, compatibility, and bioavailability. /li liDevelop and optimize sterile injectable formulations (large and small volume parenteral, ophthalmic gels, suspensions, emulsions, lyophilized products) applying QbD principles and Design of Experiments (DoE) studies. /li liDesign and execute formulation trials, dissolution studies (including pilot-scale dissolutor testing), and data-driven optimization strategies. /li liEvaluate extractables and leachable risk in collaboration with analytical team. /li liEvaluate nitrosamines risk in collaboration with analytical team. /li liSupport aseptic processing or terminal sterilization strategy selection. /li /ul /li liSupport scale-up activities and technology transfer to manufacturing. /li liCollaborate cross-functionally with Manufacturing, Quality Assurance, Quality Control and Regulatory Affairs. /li liImprove galenical development and formulations selection by attending courses, seminars and meetings. /li /ulpstrongQualifications and skills /strong /p ulliMaster’s degree or PhD in a scientific discipline (Chemistry, Industrial Chemistry, Pharmaceutical Chemistry). /li liAt least 10 years of post-degree work experience, including at least 5 years in Pharma RD context. /li liFamiliarity with both small and macro-molecules API. /li liDemonstrated expertise in injectable and/or ophthalmic formulation development. /li liProven hands-on expertise in aseptic processing, sterilization strategies, and lyophilization cycle development. /li liPractical experience applying QbD principles and/or DoE in drug product development. /li liStrong experience with late-stage development, scale-up and commercial product support. /li liFamiliarity with ICH/EU/US/Swiss laboratory guidelines related to the technical subjects. /li liExcellent command of written and spoken English. /li /ulpuPreference will be given to candidates based in Switzerland. /u /p pstrongWe offer /strong /p pFulltime permanent employment in a young working environment and positive culture.br / Sintetica promotes diversity and gender equality. /p